林奇综合征患者的类风湿性关节炎治疗极具挑
RheumatoidArthritisasaTherapeuticChallengeinaPatientwithLynchSyndrome林奇综合征患者的类风湿性关节炎治疗极具挑战Patient:Female,63FinalDiagnosis:LynchsyndromeSymptoms:—Medication:—ClinicalProcedure:MedicationadjustementSpecialty:RheumatologyObjective:Unusualsettingofmedicalcare患者：女，63岁最终诊断：林奇综合征症状：—用药：—临床过程：药物调整所涉专业：风湿病学目的：非寻常情况下的医疗护理Background:Lynchsyndrome(LS)isaninheritedcolorectalcancer(CRC)syndromeaccountingforabout3–5%ofallcasesandinvolvessignificantlyhigherriskofsubsequentmalignancies,colonicaswellasextra-colonic.Increasedriskofmalignancies,especiallylymphoidmalignancies,havebeendescribedinpatientswithautoimmunediseaseslikerheumatoidarthritis(RA),systemiclupuserythematosus,andSj?gren’ssyndrome.Epidemiologicalstudiesdemonstratedthathematopoietic,lung,skin,andprostatecancersareincreasedinRA,whilebreastandcoloncancersaredecreased,withanoverallslightincreaseinallcancers.背景：林奇综合征（LS）是一种遗传性结直肠癌（CRC）综合征，占所有结直肠癌的3-5%，后续恶性肿瘤，结肠癌和非结肠癌风险较高。风险较高的恶性肿瘤，尤其是淋巴系统恶性肿瘤，已在一些自身免疫性疾病患者中被报道，如类风湿性关节炎（RA），系统性红斑狼疮和干燥综合症。流行病学研究表明RA患者造血系统，肺，皮肤和前列腺癌增多，而乳腺癌和结肠癌减少，所有癌症整体呈略微增加趋势。CaseReport:OurcasedemonstratesthedevelopmentofCRC,endometrialcancer,andbreastcancerasapresentationofLSinapatientwithRAandpresentsatherapeuticchallengeforRAtreatment.病例报告：本例讲述的是RA患者患上CRC，子宫内膜癌和乳腺癌，表现为LS。这对RA的治疗是一大挑战。Conclusions:WedescribeapatientwithLSandRApresentingatherapeuticchallengebecausebiologicagents白癜风最新诊疗技术北京中科白殿风医院正规吗
